There is really only one good solution to deal with the permanent impermanence of life, which is to seize and appreciate each moment we are here and together with our loved ones. There are also, of course, lots of less-ideal solutions, such as merely avoiding thinking about it.

The one response that will never work: living in fear. As you say, the end shall come for all of us, hopefully later rather than sooner. I am a more cautious person than I once was, because I don’t want my own stupidity or carelessness to contribute to an early date with the end. But I mostly try to embrace the life I have and realize that when that moment does come, I’ll be able to look back and be proud of how I lived.